Work-related stress has become a pervasive issue in modern workplaces, negatively impacting employee well-being and organizational productivity. This research article examines the various sources and consequences of stress in the work environment, emphasizing the role of cognitive behavioral psychotherapy (CBT) as an effective treatment approach. The article provides an overview of the principles of CBT and explores its application in addressing work-related stress. Additionally, clinical studies supporting the efficacy of CBT in reducing stress and enhancing coping mechanisms among employees are reviewed. The findings suggest that integrating CBT into workplace interventions can lead to significant improvements in employee mental health and job performance.